Uniren Gel Mechanism of Action

Pharmacotherapeutic group: Topical Anti-Inflammatory/Anti-Rheumatic.
Pharmacology: The mechanism by which Diclofenac affects actinic keratoses is unknown. Like other Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Diclofenac inhibits the actions of prostaglandins.
Pharmacokinetics: Absorption: Approximately 10% of the Diclofenac dose was absorbed systematically following topical application four times daily for seven days.
Distribution: Volume of distribution (Vol_D) is 550 mL per Kg following oral administration of Diclofenac.
Protein binding: Very high (99%).
Biotransformation: The metabolism of topically administered Diclofenac, thought to be similar to that following oral administration, likely results in several phenolic metabolites, two of which are biologically active. Following topical administration, however, Diclofenac and its metabolites are present in the plasma in amounts too small to allow quantification of specific metabolites.
Time to peak concentration: 4.5 ± 8 hours following topical application.
Peak plasma concentration: 4 ± 5 nanograms per mL following topical application.
Elimination: Diclofenac and its metabolites are excreted mainly in the urine after oral dosing.